This detailed volume explores the condition of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and the recent techniques used to investigate the dysfunctional pathophysiology in patients. Beginning with a section on diagnosis, the book continues by covering the chronic cellular and  molecular changes in the peripheral immune system that affect their molecular homeostasis, metabolic changes, as well as imaging technologies to understand the brain s dysfunction in aberrantly regulating body physiology in ME/CFS. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.  Authoritative and practical, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Methods and Protocols serves as an ideal guide for clinicians and researchers working to better understand post-viral/stressor conditions in order to improve the lives of those affected with ME/CFS and, most recently, long COVID.