Metal-organic framework (MOF) hybrid materials could be one of the answers in this investigation. We describe a simple and effective encapsulation of doxorubicin (DOX), an anticancer drug, inside Zr-MOF, which drug delivery organizations have little studied. We investigated the measured release of the drug from Zr-MOF in response to external incentives such as pH changes and interaction with biomimetic schemes. Zr-MOF with encapsulated doxorubicin (DOX@Zr-MOF) can be manufactured in one pot by adding the anticancer medication DOX to the reaction combination. They demonstrated pH-responsive medication release and cancer cell-killing capability. MOFs can be designed as multifunctional distribution vehicles for various loads, including medicinal and imaging agents, using our simple one-pot approach. FT-IR, X-ray diffraction, scanning electron microscopy, and N2 sorption isotherm was used to analyze MOF and the developed drug delivery (DOX@Zr-MOF) scheme. It investigated the effects of MOF and a bespoke drug delivery system on the feasibility of patient breast and liver tumor cell lines.