Role of Statins in the Management of Periodontal Disease
69,00 €*
Sofort verfügbar, Lieferzeit: 1-3 Tage
Produktnummer:
9786205491119
Statins, 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA)reductase inhibitors, prescribed to prevent cardiovascular andcerebrovascular diseases.Each year they are among the most prescribed and top-selling drugs in the United States, especially in middle-aged adults. Statins have been reported to also possess anti-inflammatory properties, antibacterial activities, anti-oxidative features and pleiotropic features, such as inhibiting release of pro-inflammatory mediators and matrixmetallo-proteinases (MMPs).Due to such characteristics, statins have been used for treating patients with periodontal diseases aiming to reduce lipopolysaccharide (LPS)-induced MMP-1, MMP-8, and MMP-9 expressions in monocytes as well as expression of MMP-9 in osteoblastic cells.Statins inhibit the release of pro-inflammatory mediators, specifically cytokines(i.e., tumor necrosis factor-a, chemokines, interleukin [IL] family) and matrix metallo-proteinases (MMPs).
| Autor: | Gupta, Neetika |
|---|---|
| EAN: | 9786205491119 |
| Sprache: | Englisch |
| Seitenzahl: | 104 |
| Produktart: | kartoniert, broschiert |
| Verlag: | LAP Lambert Academic Publishing |
| Untertitel: | Statins in Treatment of Periodontal Disease. DE |
| Schlagworte: | Statins Periodontal disease inflammation bone loss |
| Größe: | 150 × 220 |
