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Paroxysmal Nocturnal Hemoglobinuria and Related Disorders

Few publications focus on the mysterious, genetically acquired disease paroxysmal nocturnal hemoglobinuria (PNH) and the related "intractable" disorders¿aplastic anemia and myelodysplastic syndromes. Now, however, the latest understanding of the clinical and molecular genetic aspects of PNH is summarized here in the proceedings of the International Symposium held in Tokyo in 2001. Major topics reviewed include the molecular mechanisms of the PIG-A gene mutation; complement activation and inhibitors; experimental animal models; pathogenesis; the history of PNH research; the natural history of the disease; the mechanism of PNH clone expansion; the emergence of PNH clones under bone marrow failure syndromes; and treatment of the disease by immunosuppressive agents and stem cell transplantation. This book provides an invaluable summary of current research on the fundamental aspects of PNH pathology, presented by renowned experts in the field.
EAN: 9784431680048
Sprache: Englisch
Seitenzahl: 304
Produktart: kartoniert, broschiert
Herausgeber: Kinoshita, T. Omine, M.
Verlag: Springer Japan Springer Japan KK
Veröffentlichungsdatum: 12.10.2012
Untertitel: Molecular Aspects of Pathogenesis
Größe: 17 × 155 × 235
Gewicht: 464 g

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